The Pediatric Nephrology, Dialysis and Transplant Unit, University of Milan is one of the nation’s largest, most experienced and innovative facilities dedicated to caring for children with kidney diseases. Our Unit provides a full range of services for the evaluation and management of infants, children, and adolescents with congenital and acquired kidney diseases. The unit also provides different techniques for renal replacement therapy including hemodialysis, peritoneal dialysis and hemofiltration/hemo-diafiltration. Moreover, the Pediatric Nephrology and Dialysis Unit of Milan has long-lasting experience in kidney transplantation in children. The unit is part of the Italian network for Pediatric Nephrology, which involves more than 30 centers across Italy and serves all children with kidney disease in Italy. The Pediatric Nephrology of Milan has been a member of the ESCAPE network since the beginning and is the PREDICT Trial coordinating centre.